[2] Santos Laguna 1-2 Unam Pumas [10] 2018-04-22 23:00
Weer: Goed Stadium: Estadio TSM Corona Veld: Goed Round: 16
Referee: Jorge Isaac Rojas Castillo Home Manager: Robert Siboldi Away Manager: David Patino Oviedo
Head to Head
| Mexico - Liga MX | 2017/11/05 18:00 | Unam Pumas v Santos Laguna | D | 2-2 |
| Mexico - Liga MX | 2017/03/05 18:00 | Unam Pumas v Santos Laguna | L | 2-1 |
| Mexico - Liga MX | 2016/09/18 23:00 | Santos Laguna v Unam Pumas | W | 3-1 |
| Wereld - Vriendschappelijke clubwedstrijden | 2016/07/02 23:00 | Unam Pumas v Santos Laguna | W | 1-2 |
| Mexico - Liga MX | 2016/02/21 18:00 | Unam Pumas v Santos Laguna | D | 1-1 |
| Mexico - Liga MX | 2015/08/29 02:30 | Santos Laguna v Unam Pumas | L | 3-4 |
| Mexico - Liga MX | 2015/04/19 17:00 | Unam Pumas v Santos Laguna | L | 1-0 |
| Mexico - Liga MX | 2014/10/25 02:30 | Santos Laguna v Unam Pumas | D | 1-1 |