[28] Western Michigan 13-35 Michigan State [9] 2022-09-02 23:00
Stadium: Spartan Stadium Round: 1
Home Manager: Melvin Tucker Away Manager: Tim Lester
Head to Head
| NCAAF | 2019/09/07 23:30 | Western Michigan v Michigan State | L | 17-51 |
| NCAAF | 2017/09/09 19:30 | Western Michigan v Michigan State | L | 14-28 |
| NCAAF | 2015/09/04 23:00 | Western Michigan v Michigan State | L | 24-37 |
| NCAAF | 2010/09/04 12:00 | Michigan State v Western Michigan | L | 38-14 |
| NCAAF | 2009/11/07 12:00 | Michigan State v Western Michigan | L | 49-14 |
| NCAAF | 2003/08/30 12:00 | Michigan State v Western Michigan | L | 26-21 |