[28] Western Michigan 13-35 Michigan State [9] 2022-09-02 23:00
Stadium: Spartan Stadium Round: 1
Home Manager: Melvin Tucker Away Manager: Tim Lester
Head to Head
| NCAAF | 2019/09/07 23:30 | Western Michigan v Michigan State | L | 17-51 |
| NCAAF | 2017/09/09 19:30 | Western Michigan v Michigan State | L | 14-28 |
| NCAAF | 2015/09/04 23:00 | Western Michigan v Michigan State | L | 24-37 |
| NCAAF | 2010/09/04 12:00 | Michigan State v Western Michigan | L | 38-14 |
| NCAAF | 2009/11/07 12:00 | Michigan State v Western Michigan | L | 49-14 |
| NCAAF | 2003/08/30 12:00 | Michigan State v Western Michigan | L | 26-21 |
Home History
| NCAAF - Bowl-wedstrijden | 2021/12/27 16:00 | Western Michigan v Nevada | W | 52-24 |
| NCAAF | 2021/11/24 00:00 | Western Michigan v Northern Illinois | W | 42-21 |
| NCAAF | 2021/11/17 00:30 | Western Michigan v Eastern Michigan | L | 21-22 |
| NCAAF | 2021/11/10 00:00 | Akron v Western Michigan | W | 40-45 |
| NCAAF | 2021/11/03 23:00 | Central Michigan v Western Michigan | L | 42-30 |
| NCAAF | 2021/10/23 19:30 | Western Michigan v Toledo | L | 15-34 |
| NCAAF | 2021/10/16 19:30 | Kent State v Western Michigan | W | 31-64 |
| NCAAF | 2021/10/09 19:30 | Ball State v Western Michigan | L | 45-20 |
Away History
| NCAAF - Bowl-wedstrijden | 2021/12/31 00:00 | Pittsburgh v Michigan State | W | 21-31 |
| NCAAF | 2021/11/27 20:30 | Penn State v Michigan State | W | 27-30 |
| NCAAF | 2021/11/20 17:00 | Michigan State v Ohio State | L | 7-56 |
| NCAAF | 2021/11/13 21:00 | Maryland v Michigan State | W | 21-40 |
| NCAAF | 2021/11/06 19:30 | Michigan State v Purdue | L | 29-40 |
| NCAAF | 2021/10/30 16:00 | Michigan v Michigan State | W | 33-37 |
| NCAAF | 2021/10/16 16:00 | Michigan State v Indiana | W | 20-15 |
| NCAAF | 2021/10/09 16:00 | Michigan State v Rutgers | W | 31-13 |