[4] East Carolina 25-27 Cincinnati [3] 2022-11-12 01:00
Stadium: Nippert Stadium Round: 1
Home Manager: Luke Fickell Away Manager: Mike Houston
Head to Head
| NCAAF | 2021/11/26 20:30 | Cincinnati v East Carolina | L | 35-13 |
| NCAAF | 2020/11/14 00:30 | East Carolina v Cincinnati | L | 17-55 |
| NCAAF | 2019/11/02 23:00 | Cincinnati v East Carolina | L | 46-43 |
| NCAAF | 2018/11/23 20:30 | East Carolina v Cincinnati | L | 6-56 |
| NCAAF | 2017/11/18 17:00 | Cincinnati v East Carolina | W | 20-48 |
| NCAAF | 2016/10/22 23:00 | East Carolina v Cincinnati | L | 19-31 |
| NCAAF | 2015/11/28 17:00 | East Carolina v Cincinnati | L | 16-19 |
| NCAAF | 2014/11/14 00:00 | Cincinnati v East Carolina | L | 54-46 |
Home History
| NCAAF | 2022/10/29 00:00 | East Carolina v BYU | W | 27-24 |
| NCAAF | 2022/10/22 23:30 | Central Florida v East Carolina | W | 13-34 |
| NCAAF | 2022/10/15 23:30 | Memphis v East Carolina | W | 45-47 |
| NCAAF | 2022/10/08 19:30 | East Carolina v Tulane | L | 9-24 |
| NCAAF | 2022/10/01 18:30 | East Carolina v South Florida | W | 48-28 |
| NCAAF | 2022/09/24 22:00 | Navy v East Carolina | L | 23-20 |
| NCAAF | 2022/09/17 22:00 | Campbell v East Carolina | W | 10-49 |
| NCAAF | 2022/09/10 22:00 | Old Dominion v East Carolina | W | 21-39 |
Away History
| NCAAF | 2022/11/05 20:00 | Navy v Cincinnati | W | 10-20 |
| NCAAF | 2022/10/29 19:30 | Cincinnati v Central Florida | L | 21-25 |
| NCAAF | 2022/10/22 16:00 | Cincinnati v SMU | W | 29-27 |
| NCAAF | 2022/10/22 16:00 | SMU v Cincinnati | W | 27-29 |
| NCAAF | 2022/10/08 18:30 | South Florida v Cincinnati | W | 24-28 |
| NCAAF | 2022/10/01 23:00 | Cincinnati v Tulsa | W | 31-21 |
| NCAAF | 2022/09/24 19:30 | Indiana v Cincinnati | W | 24-45 |
| NCAAF | 2022/09/17 16:00 | Cincinnati v Miami Ohio | W | 38-17 |