| NCAAF | 09/26 19:00 | 1 | Southern v Mississippi Valley State | L | 38-25 | |
| NCAAF | 09/18 23:00 | 1 | Mississippi Valley State v Stephen F. Austin | L | 13-58 | |
| NCAAF | 09/03 00:00 | 1 | Mississippi Valley State v Murray State | L | 0-35 | |
| NCAAF | 04/24 20:00 | 1 |
Alabama A&M
v
Mississippi Valley State
|
- | Cancelled | |
| NCAAF | 04/17 19:00 | 1 | Mississippi Valley State v Texas Southern | - | Postponed | |
| NCAAF | 04/10 19:00 | 1 |
Mississippi Valley State
v
Alabama State
|
L | 17-42 | |
| NCAAF | 04/03 20:00 | 1 |
Arkansas Pine Bluff
v
Mississippi Valley State
|
L | 24-17 | |
| NCAAF | 03/14 19:00 | 1 | Mississippi Valley State v Jackson State | L | 7-43 | |
| NCAAF | 11/23 19:00 | 1 |
Mississippi Valley State
v
Alabama A&M
|
L | 13-30 | |
| NCAAF | 11/16 19:00 | 1 | Grambling v Mississippi Valley State | L | 40-0 | |
| NCAAF | 11/02 18:00 | 1 |
Alabama St
v
Mississippi Valley State
|
L | 27-0 | |
| NCAAF | 10/26 19:00 | 1 | Texas Southern v Mississippi Valley State | W | 14-35 | |
| NCAAF | 10/19 19:00 | 1 | Jackson State v Mississippi Valley State | L | 31-28 | |
| NCAAF | 10/12 18:00 | 1 |
Mississippi Valley State
v
Arkansas Pine Bluff
|
L | 6-38 | |
| NCAAF | 10/05 20:00 | 1 | Mississippi Valley State v Lynchburg Dragons | W | 31-23 | |
| NCAAF | 09/28 23:00 | 1 | Mississippi Valley State v Alcorn St | L | 19-45 | |
| NCAAF | 09/21 23:00 | 1 | Bethune Cookman v Mississippi Valley State | L | 22-6 | |
| NCAAF | 09/07 23:00 | 1 | Mississippi Valley State v Lamar | L | 20-23 | |
| NCAAF | 08/31 23:00 | 1 | Mississippi Valley State v Tennessee State | L | 20-26 | |
| NCAAF FCS | 11/22 20:00 | 1 |
Mississippi Valley State
v
Alabama St
|
L | 24-31 | |
| NCAAF FCS | 11/17 19:00 | 1 |
Alabama A&M
v
Mississippi Valley State
|
L | 42-14 | |
| NCAAF FCS | 11/10 19:00 | 1 | Hampton v Mississippi Valley State | L | 54-39 | |
| NCAAF FCS | 11/03 19:00 | 1 | Mississippi Valley State v Grambling | L | 19-24 | |
| NCAAF | 10/27 19:00 | 1 | Texas Southern Tigers v Mississippi Valley State | L | 42-14 | |
| NCAAF | 10/20 19:00 | 1 |
Mississippi Valley State
v
Arkansas Pine Bluff
|
W | 48-47 | |
| NCAAF | 10/13 19:00 | 1 | Mississippi Valley State v Jackson State | L | 7-23 | |
| NCAAF | 10/06 20:00 | 1 | Mississippi Valley State v Bethune Cookman | L | 27-41 | |
| NCAAF | 09/22 23:00 | 1 | Alcorn St v Mississippi Valley State | L | 56-20 | |
| NCAAF | 09/08 23:00 | 1 | Mississippi Valley State v Jacksonville State | L | 0-71 | |
| NCAAF | 08/30 23:30 | 1 | Mississippi Valley State v North Dakota | L | 7-35 |