Notre Dame 27-38 USC 2022-11-27 00:30
Stadium: Los Angeles Memorial Coliseum Round: 1
Home Manager: Lincoln Riley Away Manager: Marcus Freeman
Head to Head
| NCAAF | 2021/10/23 23:30 | USC v Notre Dame | W | 16-31 |
| NCAAF | 2019/10/12 23:30 | USC v Notre Dame | W | 27-30 |
| NCAAF | 2018/11/25 01:00 | Notre Dame v USC | W | 24-17 |
| NCAAF | 2017/10/21 23:30 | USC v Notre Dame | W | 14-49 |
| NCAAF | 2016/11/26 20:30 | Notre Dame v USC | L | 27-45 |
| NCAAF | 2015/10/17 23:30 | Notre Dame v USC | W | 41-31 |
| NCAAF | 2014/11/29 20:30 | USC v Notre Dame | L | 49-14 |
| NCAAF | 2012/11/24 12:00 | USC v Notre Dame | W | 13-22 |
| NCAAF | 2011/10/22 12:00 | Notre Dame v USC | L | 17-31 |
| NCAAF | 2010/11/27 12:00 | USC v Notre Dame | W | 16-20 |
| NCAAF | 2009/10/17 12:00 | Notre Dame v USC | L | 27-34 |
| NCAAF | 2008/11/29 12:00 | USC v Notre Dame | L | 38-3 |
| NCAAF | 2007/10/20 12:00 | Notre Dame v USC | L | 0-38 |
| NCAAF | 2006/11/25 12:00 | USC v Notre Dame | L | 44-24 |
| NCAAF | 2005/10/15 12:00 | Notre Dame v USC | L | 31-34 |
| NCAAF | 2004/11/27 12:00 | USC v Notre Dame | L | 41-10 |
| NCAAF | 2003/10/18 12:00 | Notre Dame v USC | L | 14-45 |
| NCAAF | 2002/11/30 12:00 | USC v Notre Dame | L | 44-13 |
| NCAAF | 2001/10/20 12:00 | Notre Dame v USC | W | 27-16 |
| NCAAF | 2000/11/25 12:00 | USC v Notre Dame | W | 21-38 |