[2] Colo Colo 4-0 Union La Calera [11] 2022-03-31 22:00
Stadium: Monumental David Arellano Round: 8
Referee: Fernando Vejar Home Manager: Gustavo Quinteros Away Manager: Martin Anselmi
Head to Head
| Chili - Primera División | 2021/08/25 20:30 | Union La Calera v Colo Colo | D | 1-1 |
| Chili - Primera División | 2021/03/27 21:30 | Colo Colo v Union La Calera | D | 0-0 |
| Chili - Primera División | 2021/01/31 21:30 | Colo Colo v Union La Calera | W | 2-1 |
| Chili - Primera División | 2020/09/12 21:30 | Union La Calera v Colo Colo | D | 0-0 |
| Chili - Primera División | 2019/05/05 19:00 | Union La Calera v Colo Colo | D | 1-1 |
| Chili - Primera División | 2018/07/21 16:00 | Union La Calera v Colo Colo | W | 1-2 |
| Chili - Primera División | 2018/05/29 00:00 | Colo Colo v Union La Calera | L | 0-2 |
| Chile Clausura | 2016/02/21 20:00 | Union La Calera v Colo Colo | W | 0-1 |
| Chile Apertura | 2015/09/14 22:30 | Colo Colo v Union La Calera | W | 3-1 |
| Chile Clausura | 2015/03/21 21:00 | Colo Colo v Union La Calera | L | 1-4 |
| Chile Apertura | 2014/10/26 18:30 | Union La Calera v Colo Colo | W | 0-2 |