[10] River Plate Asuncion 1-1 Cerro Porteno [3] 2021-05-16 21:45
Stadium: Estadio River Plate Round: 16
Referee: Eber Aquino Home Manager: Celso Rafael Ayala Gavilan Away Manager: Francisco Arce
Head to Head
| Paraguay - División Profesional | 2021/03/09 23:45 | Cerro Porteno v River Plate Asuncion | L | 3-0 |
| Paraguay - División Profesional | 2020/11/20 21:30 | River Plate Asuncion v Cerro Porteno | L | 1-2 |
| Paraguay - División Profesional | 2020/09/26 23:30 | Cerro Porteno v River Plate Asuncion | L | 3-1 |
| Paraguay - División Profesional | 2020/07/25 22:30 | River Plate Asuncion v Cerro Porteno | L | 0-2 |
| Paraguay - División Profesional | 2019/11/27 23:00 | River Plate Asuncion v Cerro Porteno | L | 1-2 |
| Paraguay - División Profesional | 2019/09/02 23:00 | Cerro Porteno v River Plate Asuncion | L | 2-0 |
| Paraguay - División Profesional | 2019/04/13 23:30 | River Plate Asuncion v Cerro Porteno | L | 1-5 |
| Paraguay - División Profesional | 2019/02/10 23:30 | Cerro Porteno v River Plate Asuncion | L | 3-1 |
| Paraguay - Beker | 2018/10/24 22:15 | Cerro Porteno v River Plate Asuncion | L | 1-0 |
| Paraguay - División Profesional | 2016/12/02 21:00 | Cerro Porteno v River Plate Asuncion | L | 4-0 |
| Paraguay - División Profesional | 2016/08/28 23:15 | River Plate Asuncion v Cerro Porteno | L | 2-3 |
| Paraguay - División Profesional | 2016/03/31 22:30 | Cerro Porteno v River Plate Asuncion | L | 4-0 |
| Paraguay - División Profesional | 2016/01/24 22:00 | River Plate Asuncion v Cerro Porteno | L | 0-2 |