| Uruguay - Reserve League | 2018/05/08 18:00 | Penarol - Reserves v Defensor Sporting - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2018/05/02 18:00 | Defensor Sporting - Reserves v Boston River - Reserves | W | 3-2 |
| Uruguay - Reserve League | 2018/04/17 13:00 | Defensor Sporting - Reserves v Liverpool Montevideo - Reserves | L | 1-2 |
| Uruguay - Reserve League | 2018/04/10 19:00 | Montevideo Wanderers - Reserves v Defensor Sporting - Reserves | W | 0-3 |
| Uruguay - Reserve League | 2018/04/01 16:30 | Defensor Sporting - Reserves v Atletico River Plate Reserves | L | 1-2 |
| Uruguay - Reserve League | 2018/03/17 17:00 | Defensor Sporting - Reserves v Progreso - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2018/03/13 13:00 | Nacional de Montevideo - Reserves v Defensor Sporting - Reserves | D | 2-2 |
| Uruguay - Reserve League | 2018/03/04 20:00 | Defensor Sporting - Reserves v Atletico Fenix - Reserves | L | 0-1 |
| Uruguay - Reserve League | 2018/07/25 13:00 | Danubio - Reserves v Progreso - Reserves | W | 2-0 |
| Uruguay - Reserve League | 2018/05/22 18:00 | Danubio - Reserves v Boston River - Reserves | W | 6-3 |
| Uruguay - Reserve League | 2018/05/15 18:00 | Penarol - Reserves v Danubio - Reserves | W | 1-3 |
| Uruguay - Reserve League | 2018/05/09 18:30 | Danubio - Reserves v Nacional de Montevideo - Reserves | W | 2-0 |
| Uruguay - Reserve League | 2018/05/02 18:30 | Atletico Fenix - Reserves v Danubio - Reserves | L | 5-3 |
| Uruguay - Reserve League | 2018/04/18 13:00 | Torque - Reserves v Danubio - Reserves | W | 0-6 |
| Uruguay - Reserve League | 2018/04/11 13:00 | CA Cerro - Reserves v Danubio - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2018/04/01 16:15 | Danubio - Reserves v Atenas Reserves | D | 1-1 |