| Uruguay - Reserve League | 2022/09/12 18:00 | Defensor Sporting - Reserves v Penarol - Reserves | W | 2-1 |
| Uruguay - Reserve League | 2019/09/18 13:30 | Penarol - Reserves v Defensor Sporting - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2018/11/06 19:00 | Defensor Sporting - Reserves v Penarol - Reserves | W | 1-0 |
| Uruguay - Reserve League | 2018/05/08 18:00 | Penarol - Reserves v Defensor Sporting - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2017/10/24 18:00 | Penarol - Reserves v Defensor Sporting - Reserves | W | 2-3 |
| Uruguay - Reserve League | 2022/12/08 19:00 | Defensor Sporting - Reserves v Rentistas - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2022/12/05 13:00 | Deportivo Maldonado - Reserves v Defensor Sporting - Reserves | L | 2-1 |
| Uruguay - Reserve League | 2022/12/01 19:00 | Defensor Sporting - Reserves v Danubio - Reserves | L | 0-5 |
| Uruguay - Reserve League | 2022/11/24 19:00 | Cerrito - Reserves v Defensor Sporting - Reserves | W | 0-1 |
| Uruguay - Reserve League | 2022/11/21 19:00 | Nacional de Montevideo - Reserves v Defensor Sporting - Reserves | L | 3-1 |
| Uruguay - Reserve League | 2022/11/14 12:30 | Defensor Sporting - Reserves v Albion FC - Reserves | W | 5-1 |
| Uruguay - Reserve League | 2022/11/04 13:00 | Atletico Fenix - Reserves v Defensor Sporting - Reserves | L | 5-0 |
| Uruguay - Reserve League | 2022/10/25 18:00 | Defensor Sporting - Reserves v Cerro Largo - Reserves | W | 4-0 |
| Uruguay - Reserve League | 2023/02/20 12:45 | Penarol - Reserves v Boston River - Reserves | W | 3-1 |
| Uruguay - Reserve League | 2022/12/05 12:00 | Penarol - Reserves v Atletico River Plate Reserves | W | 3-1 |
| Uruguay - Reserve League | 2022/12/01 12:30 | Boston River - Reserves v Penarol - Reserves | W | 0-5 |
| Uruguay - Reserve League | 2022/11/24 19:00 | Liverpool Montevideo - Reserves v Penarol - Reserves | L | 4-1 |
| Uruguay - Reserve League | 2022/11/21 19:00 | Penarol - Reserves v Plaza Colonia - Reserves | W | 3-2 |
| Uruguay - Reserve League | 2022/11/14 19:00 | Montevideo Wanderers - Reserves v Penarol - Reserves | W | 1-2 |
| Uruguay - Reserve League | 2022/11/08 19:00 | Penarol - Reserves v Torque - Reserves | W | 5-0 |
| Uruguay - Reserve League | 2022/11/04 18:00 | Cerrito - Reserves v Penarol - Reserves | W | 1-5 |