| Uruguay - Reserve League | 2022/06/14 18:00 | Rentistas - Reserves v Defensor Sporting - Reserves | L | 3-1 |
| Uruguay - Reserve League | 2022/12/05 13:00 | Deportivo Maldonado - Reserves v Defensor Sporting - Reserves | L | 2-1 |
| Uruguay - Reserve League | 2022/12/01 19:00 | Defensor Sporting - Reserves v Danubio - Reserves | L | 0-5 |
| Uruguay - Reserve League | 2022/11/24 19:00 | Cerrito - Reserves v Defensor Sporting - Reserves | W | 0-1 |
| Uruguay - Reserve League | 2022/11/21 19:00 | Nacional de Montevideo - Reserves v Defensor Sporting - Reserves | L | 3-1 |
| Uruguay - Reserve League | 2022/11/14 12:30 | Defensor Sporting - Reserves v Albion FC - Reserves | W | 5-1 |
| Uruguay - Reserve League | 2022/11/04 13:00 | Atletico Fenix - Reserves v Defensor Sporting - Reserves | L | 5-0 |
| Uruguay - Reserve League | 2022/10/25 18:00 | Defensor Sporting - Reserves v Cerro Largo - Reserves | W | 4-0 |
| Uruguay - Reserve League | 2022/10/11 13:00 | Atletico River Plate Reserves v Defensor Sporting - Reserves | D | 0-0 |
| Uruguay - Reserve League | 2022/12/05 19:00 | Rentistas - Reserves v Atletico Fenix - Reserves | W | 1-0 |
| Uruguay - Reserve League | 2022/11/21 19:00 | Rentistas - Reserves v Atletico River Plate Reserves | D | 2-2 |
| Uruguay - Reserve League | 2022/11/14 19:00 | Boston River - Reserves v Rentistas - Reserves | D | 3-3 |
| Uruguay - Reserve League | 2022/11/10 19:00 | Rentistas - Reserves v Liverpool Montevideo - Reserves | D | 2-2 |
| Uruguay - Reserve League | 2022/11/08 13:00 | Rentistas - Reserves v Plaza Colonia - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2022/11/03 18:00 | Montevideo Wanderers - Reserves v Rentistas - Reserves | L | 5-0 |
| Uruguay - Reserve League | 2022/10/25 18:00 | Rentistas - Reserves v Torque - Reserves | L | 1-2 |
| Uruguay - Reserve League | 2022/10/17 18:00 | Rentistas - Reserves v Danubio - Reserves | D | 1-1 |