| Uruguay - Reserve League | 2022/05/31 18:00 | Danubio - Reserves v Defensor Sporting - Reserves | W | 0-3 |
| Uruguay - Reserve League | 2019/11/07 19:00 | Defensor Sporting - Reserves v Danubio - Reserves | W | 3-1 |
| Uruguay - Reserve League | 2019/04/16 18:00 | Danubio - Reserves v Defensor Sporting - Reserves | W | 2-5 |
| Uruguay - Reserve League | 2018/08/01 18:00 | Defensor Sporting - Reserves v Danubio - Reserves | L | 0-3 |
| Uruguay - Reserve League | 2022/11/24 19:00 | Cerrito - Reserves v Defensor Sporting - Reserves | W | 0-1 |
| Uruguay - Reserve League | 2022/11/21 19:00 | Nacional de Montevideo - Reserves v Defensor Sporting - Reserves | L | 3-1 |
| Uruguay - Reserve League | 2022/11/14 12:30 | Defensor Sporting - Reserves v Albion FC - Reserves | W | 5-1 |
| Uruguay - Reserve League | 2022/11/04 13:00 | Atletico Fenix - Reserves v Defensor Sporting - Reserves | L | 5-0 |
| Uruguay - Reserve League | 2022/10/25 18:00 | Defensor Sporting - Reserves v Cerro Largo - Reserves | W | 4-0 |
| Uruguay - Reserve League | 2022/10/11 13:00 | Atletico River Plate Reserves v Defensor Sporting - Reserves | D | 0-0 |
| Uruguay - Reserve League | 2022/09/27 13:00 | Defensor Sporting - Reserves v Boston River - Reserves | L | 2-3 |
| Uruguay - Reserve League | 2022/09/12 18:00 | Defensor Sporting - Reserves v Penarol - Reserves | W | 2-1 |
| Uruguay - Reserve League | 2022/11/25 13:00 | Albion FC - Reserves v Danubio - Reserves | W | 1-2 |
| Uruguay - Reserve League | 2022/11/21 13:00 | Danubio - Reserves v Atletico Fenix - Reserves | L | 1-3 |
| Uruguay - Reserve League | 2022/11/08 13:00 | Danubio - Reserves v Atletico River Plate Reserves | W | 1-0 |
| Uruguay - Reserve League | 2022/11/04 12:00 | Boston River - Reserves v Danubio - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2022/10/25 14:00 | Danubio - Reserves v Plaza Colonia - Reserves | D | 0-0 |
| Uruguay - Reserve League | 2022/10/17 18:00 | Rentistas - Reserves v Danubio - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2022/10/11 18:00 | Danubio - Reserves v Liverpool Montevideo - Reserves | W | 5-1 |
| Uruguay - Reserve League | 2022/10/03 18:00 | Montevideo Wanderers - Reserves v Danubio - Reserves | D | 2-2 |