[1] Ohio State 21-7 Northwestern [4] 2022-11-05 16:00
Stadium: Ryan Field Round: 1
Home Manager: Pat Fitzgerald Away Manager: Ryan Day
Head to Head
| NCAAF | 2020/12/19 17:00 | Northwestern v Ohio State | W | 10-22 |
| NCAAF | 2019/10/19 00:30 | Ohio State v Northwestern | W | 52-3 |
| NCAAF | 2018/12/02 01:00 | Northwestern v Ohio State | W | 24-45 |
| NCAAF | 2016/10/29 19:30 | Northwestern v Ohio State | W | 20-24 |
| NCAAF | 2008/11/08 12:00 | Northwestern v Ohio State | W | 10-45 |
| NCAAF | 2007/09/22 12:00 | Ohio State v Northwestern | W | 58-7 |
| NCAAF | 2006/11/11 12:00 | Northwestern v Ohio State | W | 10-54 |
| NCAAF | 2005/11/12 12:00 | Ohio State v Northwestern | W | 48-7 |
Home History
| NCAAF | 2022/10/29 16:00 | Ohio State v Penn State | W | 44-31 |
| NCAAF | 2022/10/22 16:00 | Iowa v Ohio State | W | 10-54 |
| NCAAF | 2022/10/08 20:00 | Ohio State v Michigan State | W | 49-20 |
| NCAAF | 2022/10/01 19:30 | Rutgers v Ohio State | W | 10-49 |
| NCAAF | 2022/09/24 23:30 | Wisconsin v Ohio State | W | 21-52 |
| NCAAF | 2022/09/17 23:00 | Toledo v Ohio State | W | 21-77 |
| NCAAF | 2022/09/10 16:00 | Arkansas State v Ohio State | W | 12-45 |
| NCAAF | 2022/09/03 23:30 | Notre Dame v Ohio State | W | 10-21 |
Away History
| NCAAF | 2022/10/29 19:30 | Northwestern v Iowa | L | 13-33 |
| NCAAF | 2022/10/22 19:30 | Northwestern v Maryland | L | 24-31 |
| NCAAF | 2022/10/08 19:30 | Wisconsin v Northwestern | L | 42-7 |
| NCAAF | 2022/10/01 19:30 | Northwestern v Penn State | L | 7-17 |
| NCAAF | 2022/09/24 23:30 | Miami Ohio v Northwestern | L | 17-14 |
| NCAAF | 2022/09/17 16:00 | SO Illinois v Northwestern | L | 31-24 |
| NCAAF | 2022/09/10 16:00 | Duke v Northwestern | L | 31-23 |
| NCAAF | 2022/08/27 16:30 | Northwestern v Nebraska | W | 31-28 |