Stadium: Manning Field at John L. Guidry Stadium Round: 1
Home Manager: Tim Rebowe Away Manager: David Bailiff
| NCAAF | 2022/11/05 19:00 | Northwestern State v Texas A&M-Commerce | L | 41-14 |
| NCAAF | 2022/10/29 19:00 | Incarnate Word v Texas A&M-Commerce | L | 35-7 |
| NCAAF | 2022/10/22 19:00 | Houston Christian v Texas A&M-Commerce | W | 3-31 |
| NCAAF | 2022/10/16 00:00 | Texas A&M-Commerce v McNeese State | W | 40-15 |
| NCAAF | 2022/10/08 21:00 | Texas A&M-Commerce v SE Louisiana | W | 31-28 |
| NCAAF | 2022/09/24 23:00 | Texas A&M-Commerce v North American Stallions | W | 63-3 |
| NCAAF | 2022/09/17 23:00 | Texas A&M-Commerce v Sam Houston State | L | 17-27 |
| NCAAF | 2022/09/10 23:00 | Texas A&M-Commerce v Tennessee Tech | L | 25-26 |
| NCAAF | 2022/10/29 20:00 | Nicholls State v Lamar | L | 17-24 |
| NCAAF | 2022/10/22 20:00 | McNeese State v Nicholls State | W | 35-40 |
| NCAAF | 2022/10/15 20:00 | Incarnate Word v Nicholls State | L | 49-14 |
| NCAAF | 2022/10/08 23:00 | Nicholls State v Houston Christian | W | 19-17 |
| NCAAF | 2022/10/01 20:30 | Nicholls State v Northwestern State | L | 33-36 |
| NCAAF | 2022/09/24 20:00 | Jacksonville State v Nicholls State | L | 52-21 |
| NCAAF | 2022/09/17 19:00 | Nicholls State v SE Missouri St | L | 16-42 |
| NCAAF | 2022/09/11 00:00 | Nicholls State v UL Monroe | L | 7-35 |