Stadium: Husky Stadium Round: 1
Home Manager: Vic Shealy Away Manager: Gary Goff
| NCAAF | 2021/11/13 20:00 | McNeese State v Houston Christian | W | 44-3 |
| NCAAF | 2019/10/19 21:00 | Houston Christian v McNeese State | W | 27-42 |
| NCAAF | 2018/09/08 23:00 | McNeese State v Houston Christian | W | 51-34 |
| NCAAF | 2017/09/23 23:00 | Houston Christian v McNeese State | W | 12-27 |
| NCAAF | 2022/11/06 00:00 | Eastern Illinois v McNeese State | W | 15-29 |
| NCAAF | 2022/10/30 00:00 | SE Louisiana v McNeese State | L | 28-27 |
| NCAAF | 2022/10/22 20:00 | McNeese State v Nicholls State | L | 35-40 |
| NCAAF | 2022/10/16 00:00 | Texas A&M-Commerce v McNeese State | L | 40-15 |
| NCAAF | 2022/10/01 23:00 | McNeese State v Incarnate Word | L | 20-48 |
| NCAAF | 2022/09/25 00:00 | McNeese State v Mississippi College Choctaws | W | 32-17 |
| NCAAF | 2022/09/18 00:00 | Alcorn State v McNeese State | L | 30-19 |
| NCAAF | 2022/09/10 23:30 | McNeese State v Rice | L | 10-52 |
| NCAAF | 2022/11/05 19:00 | Houston Christian v Incarnate Word | L | 20-73 |
| NCAAF | 2022/10/29 19:00 | Tennessee Martin v Houston Christian | L | 52-28 |
| NCAAF | 2022/10/22 19:00 | Houston Christian v Texas A&M-Commerce | L | 3-31 |
| NCAAF | 2022/10/15 23:00 | Northwestern State v Houston Christian | L | 37-10 |
| NCAAF | 2022/10/08 23:00 | Nicholls State v Houston Christian | L | 19-17 |
| NCAAF | 2022/10/01 20:00 | Houston Christian v Lamar | W | 37-34 |
| NCAAF | 2022/09/24 23:00 | Houston Christian v Texas State | L | 0-34 |
| NCAAF | 2022/09/10 23:00 | Lindenwood v Houston Christian | L | 21-20 |