| Uruguay - Reserve League | 2022/06/06 18:00 | Atletico Fenix - Reserves v Rentistas - Reserves | D | 0-0 |
| Uruguay - Reserve League | 2022/05/31 18:00 | Rentistas - Reserves v Cerro Largo - Reserves | L | 0-2 |
| Uruguay - Reserve League | 2022/05/24 13:00 | Atletico River Plate Reserves v Rentistas - Reserves | L | 2-1 |
| Uruguay - Reserve League | 2022/05/19 18:00 | Rentistas - Reserves v Boston River - Reserves | W | 3-2 |
| Uruguay - Reserve League | 2022/05/10 13:30 | Plaza Colonia - Reserves v Rentistas - Reserves | W | 1-2 |
| Uruguay - Reserve League | 2022/05/02 18:00 | Rentistas - Reserves v Montevideo Wanderers - Reserves | L | 0-1 |
| Uruguay - Reserve League | 2022/04/05 19:00 | Rentistas - Reserves v Penarol - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2022/03/28 19:00 | Liverpool Montevideo - Reserves v Rentistas - Reserves | L | 3-2 |
| Uruguay - Reserve League | 2022/06/06 18:00 | Defensor Sporting - Reserves v Deportivo Maldonado - Reserves | D | 1-1 |
| Uruguay - Reserve League | 2022/05/31 18:00 | Danubio - Reserves v Defensor Sporting - Reserves | W | 0-3 |
| Uruguay - Reserve League | 2022/05/26 17:00 | Albion FC - Reserves v Defensor Sporting - Reserves | L | 1-0 |
| Uruguay - Reserve League | 2022/05/24 17:00 | Defensor Sporting - Reserves v Nacional de Montevideo - Reserves | L | 1-3 |
| Uruguay - Reserve League | 2022/05/10 18:00 | Defensor Sporting - Reserves v Cerrito - Reserves | W | 3-1 |
| Uruguay - Reserve League | 2022/05/02 18:00 | Defensor Sporting - Reserves v Atletico Fenix - Reserves | L | 0-2 |
| Uruguay - Reserve League | 2022/04/05 19:00 | Defensor Sporting - Reserves v Atletico River Plate Reserves | L | 0-2 |
| Uruguay - Reserve League | 2022/03/29 19:00 | Boston River - Reserves v Defensor Sporting - Reserves | D | 1-1 |