Round: 5
| El Salvador - Reserve league | 2021/11/18 17:00 | Once Deportivo de Ahuachapán - Reserves v AD Isidro Metapan - Reserves | W | 3-1 |
| El Salvador - Reserve league | 2021/09/16 21:00 | AD Isidro Metapan - Reserves v Once Deportivo de Ahuachapán - Reserves | D | 2-2 |
| El Salvador - Reserve league | 2021/03/10 18:30 | Once Deportivo de Ahuachapán - Reserves v AD Isidro Metapan - Reserves | D | 1-1 |
| El Salvador - Reserve league | 2021/02/18 18:45 | AD Isidro Metapan - Reserves v Once Deportivo de Ahuachapán - Reserves | L | 4-1 |
| El Salvador - Reserve league | 2020/02/26 18:02 | Once Deportivo de Ahuachapán - Reserves v AD Isidro Metapan - Reserves | L | 2-3 |
| El Salvador - Reserve league | 2022/01/29 18:00 | Atletico Marte - Reserves v Once Deportivo de Ahuachapán - Reserves | W | 1-2 |
| El Salvador - Reserve league | 2022/01/26 18:00 | Once Deportivo de Ahuachapán - Reserves v Municipal Limeno - Reserves | L | 1-2 |
| El Salvador - Reserve league | 2022/01/22 21:00 | Santa Tecla Reserves v Once Deportivo de Ahuachapán - Reserves | L | 3-1 |
| El Salvador - Reserve league | 2022/01/16 18:00 | Once Deportivo de Ahuachapán - Reserves v CD FAS - Reserves | D | 0-0 |
| El Salvador - Reserve league | 2021/12/05 18:00 | Alianza FC San Salvador - Reserves v Once Deportivo de Ahuachapán - Reserves | L | 6-4 |
| El Salvador - Reserve league | 2021/12/02 18:00 | Once Deportivo de Ahuachapán - Reserves v Alianza FC San Salvador - Reserves | D | 0-0 |
| El Salvador - Reserve league | 2021/11/27 17:00 | Once Deportivo de Ahuachapán - Reserves v Santa Tecla Reserves | W | 3-0 |
| El Salvador - Reserve league | 2021/11/22 18:00 | Atletico Marte - Reserves v Once Deportivo de Ahuachapán - Reserves | L | 3-1 |
| El Salvador - Reserve league | 2022/01/29 21:00 | AD Isidro Metapan - Reserves v CD Platense Zacatecoluca - Reserves | W | 4-1 |
| El Salvador - Reserve league | 2022/01/26 22:00 | CD Luis Angel Firpo - Reserves v AD Isidro Metapan - Reserves | D | 2-2 |
| El Salvador - Reserve league | 2022/01/22 21:00 | AD Isidro Metapan - Reserves v AD Chalatenago - Reserves | D | 1-1 |
| El Salvador - Reserve league | 2022/01/16 18:00 | Alianza FC San Salvador - Reserves v AD Isidro Metapan - Reserves | L | 3-1 |
| El Salvador - Reserve league | 2021/12/04 22:00 | Santa Tecla Reserves v AD Isidro Metapan - Reserves | L | 3-0 |
| El Salvador - Reserve league | 2021/12/01 21:00 | AD Isidro Metapan - Reserves v Santa Tecla Reserves | W | 2-1 |
| El Salvador - Reserve league | 2021/11/21 19:00 | AD Isidro Metapan - Reserves v CD FAS - Reserves | D | 0-0 |
| El Salvador - Reserve league | 2021/11/18 17:00 | Once Deportivo de Ahuachapán - Reserves v AD Isidro Metapan - Reserves | L | 3-1 |