[10] Charlotte FC 2-1 Vancouver Whitecaps [14] 2022-05-22 21:00
Stadium: Bank of America Stadium
Referee: Nima Saghafi Home Manager: Miguel Ramirez Away Manager: Vanni Sartini
Home History
| VS - MLS | 2022/05/14 23:00 | Charlotte FC v CF Montreal | L | 0-2 |
| VS - US Open Cup | 2022/05/11 22:30 | Richmond Kickers v Charlotte FC | W | 1-5 |
| VS - MLS | 2022/05/07 19:30 | Charlotte FC v Inter Miami CF | W | 1-0 |
| VS - MLS | 2022/04/30 23:30 | Orlando City SC v Charlotte FC | L | 2-1 |
| VS - MLS | 2022/04/24 01:00 | Colorado Rapids v Charlotte FC | D | 0-0 |
| VS - US Open Cup | 2022/04/20 23:00 | Greenville Triumph SC v Charlotte FC | W | 1-2 |
| VS - MLS | 2022/04/16 23:30 | New England Revolution v Charlotte FC | L | 2-1 |
| VS - MLS | 2022/04/10 17:30 | Charlotte FC v Atlanta United | W | 1-0 |
Away History
| VS - MLS | 2022/05/19 02:00 | Vancouver Whitecaps v FC Dallas | W | 2-1 |
| VS - MLS | 2022/05/14 23:00 | Vancouver Whitecaps v San Jose Earthquakes | D | 3-3 |
| Canada - Championship | 2022/05/12 02:00 | Vancouver Whitecaps v Valour FC | W | 2-0 |
| VS - MLS | 2022/05/08 20:00 | Vancouver Whitecaps v Toronto FC | W | 1-0 |
| VS - MLS | 2022/04/24 00:30 | Austin FC v Vancouver Whitecaps | L | 3-0 |
| VS - MLS | 2022/04/16 19:00 | CF Montreal v Vancouver Whitecaps | L | 2-1 |
| VS - MLS | 2022/04/10 02:00 | Vancouver Whitecaps v Portland Timbers | L | 2-3 |
| VS - MLS | 2022/04/03 00:00 | Vancouver Whitecaps v Sporting Kansas City | W | 1-0 |