[4] Alexander Zverev 7-6,6-7,10-5 John Isner [22] 2021-09-25 18:50
Stadium: Center Court Round: 44 Ground: Hardcourt indoor
Head to Head
| Laver Cup | 2019/09/21 11:00 | Alexander Zverev v John Isner | 7-6,4-6,1-10 |
| ATP - World Tour Finals | 2018/11/16 14:00 | Alexander Zverev v John Isner | 7-6,6-3 |
| Laver Cup | 2018/09/22 18:00 | Alexander Zverev v John Isner | 3-6,7-6,10-7 |
| ATP - Madrid | 2018/05/11 20:00 | John Isner v Alexander Zverev | 4-6,5-7 |
| ATP - Miami | 2018/04/01 17:00 | Alexander Zverev v John Isner | 7-6,4-6,4-6 |
| ATP - Rome | 2017/05/20 13:00 | Alexander Zverev v John Isner | 6-4,6-7,6-1 |
| ATP - Miami | 2017/03/27 20:40 | John Isner v Alexander Zverev | 7-6,6-7,6-7 |
| ATP - Shanghai | 2016/10/10 07:10 | Alexander Zverev v John Isner | 6-4,6-2 |
Home History
| US Open | 2021/09/10 23:00 | Novak Djokovic v Alexander Zverev | 4-6,6-2,6-4,4-6,6-2 |
| US Open | 2021/09/08 17:45 | Alexander Zverev v Lloyd Harris | 7-6,6-3,6-4 |
| US Open | 2021/09/06 16:00 | Alexander Zverev v Jannik Sinner | 6-4,6-4,7-6 |
| US Open | 2021/09/02 17:50 | Alexander Zverev v Albert Ramos-Vinolas | 6-1,6-0,6-3 |
| US Open | 2021/08/31 16:00 | Alexander Zverev v Sam Querrey | 6-4,7-5,6-2 |
| ATP - Cincinnati | 2021/08/22 20:30 | Andrey Rublev v Alexander Zverev | 2-6,3-6 |
| ATP - Cincinnati | 2021/08/21 22:00 | Alexander Zverev v Stefanos Tsitsipas | 6-4,3-6,7-6 |
| ATP - Cincinnati | 2021/08/21 00:30 | Casper Ruud v Alexander Zverev | 1-6,3-6 |
Away History
| US Open | 2021/08/30 17:35 | John Isner v Brandon Nakashima | 6-7,6-7,3-6 |
| ATP - Cincinnati | 2021/08/19 16:05 | John Isner v Benoit Paire | 6-7,7-6,1-6 |
| ATP - Cincinnati | 2021/08/18 19:35 | Jannik Sinner v John Isner | 7-5,6-7,4-6 |
| ATP - Cincinnati | 2021/08/17 17:55 | John Isner v Cameron Norrie | 4-6,7-6,6-4 |
| ATP - Toronto | 2021/08/15 00:00 | Daniil Medvedev v John Isner | 6-2,6-2 |
| ATP - Toronto | 2021/08/14 01:35 | John Isner v Gael Monfils | 7-6,6-4 |
| ATP - Toronto | 2021/08/12 16:35 | Andrey Rublev v John Isner | 5-7,6-7 |
| ATP - Toronto | 2021/08/11 15:00 | John Isner v Cristian Garin | 4-6,6-3,6-4 |