Stadium: Panther Stadium at Blackshear Field Round: 1
Home Manager: Eric Dooley Away Manager: Vincent Dancy
| NCAAF | 2021/11/13 19:00 | Alabama State v Mississippi Valley State | W | 31-44 |
| NCAAF | 2021/11/06 18:00 | Mississippi Valley State v Alabama | L | 14-42 |
| NCAAF | 2021/10/30 20:00 | Jackson State v Mississippi Valley State | L | 28-19 |
| NCAAF | 2021/10/23 20:00 | Florida A&M v Mississippi Valley State | L | 31-28 |
| NCAAF | 2021/10/16 20:00 | Alcorn State v Mississippi Valley State | L | 24-12 |
| NCAAF | 2021/10/09 20:00 | Mississippi Valley State v Bethune Cookman | W | 20-14 |
| NCAAF | 2021/10/02 20:00 | North Carolina Central v Mississippi Valley State | W | 16-17 |
| NCAAF | 2021/09/26 19:00 | Southern v Mississippi Valley State | L | 38-25 |
| NCAAF | 2021/11/20 17:00 | Prairie View v Texas A&M | L | 3-52 |
| NCAAF | 2021/11/13 20:00 | Prairie View v Alcorn State | L | 29-31 |
| NCAAF | 2021/11/06 19:00 | Alabama State v Prairie View | W | 20-24 |
| NCAAF | 2021/10/23 23:00 | Prairie View v Southern | W | 48-21 |
| NCAAF | 2021/10/16 17:00 | Prairie View v Bethune Cookman | W | 35-29 |
| NCAAF | 2021/09/30 23:30 | Arkansas Pine Bluff v Prairie View | W | 17-27 |
| NCAAF | 2021/09/25 21:00 | Grambling State v Prairie View | W | 10-24 |
| NCAAF | 2021/09/18 23:00 | Houston Christian v Prairie View | W | 27-37 |