Stadium: Gayle and Tom Benson Stadium Round: 1
Home Manager: Eric Morris Away Manager: Vic Shealy
| NCAAF | 2021/10/23 23:00 | Nicholls State v Houston Christian | L | 44-14 |
| NCAAF | 2021/10/16 21:00 | Houston Christian v SE Louisiana | L | 24-61 |
| NCAAF | 2021/10/09 23:00 | Northwestern State v Houston Christian | L | 21-17 |
| NCAAF | 2021/10/02 20:00 | Houston Christian v Nicholls State | L | 17-48 |
| NCAAF | 2021/09/18 23:00 | Houston Christian v Prairie View | L | 27-37 |
| NCAAF | 2021/09/11 23:00 | Northern Colorado v Houston Christian | L | 45-13 |
| NCAAF | 2021/09/03 00:00 | Houston Christian v New Mexico | L | 17-27 |
| NCAAF | 2020/10/03 19:00 | Houston Christian v Eastern Kentucky | W | 33-30 |
| NCAAF | 2021/10/23 17:00 | Incarnate Word v McNeese State | L | 20-28 |
| NCAAF | 2021/10/16 16:00 | Nicholls State v Incarnate Word | W | 21-38 |
| NCAAF | 2021/10/02 23:00 | Incarnate Word v Northwestern State | W | 38-27 |
| NCAAF | 2021/09/25 16:00 | McNeese State v Incarnate Word | W | 0-31 |
| NCAAF | 2021/09/18 23:00 | Incarnate Word v Texas State | W | 42-34 |
| NCAAF | 2021/09/12 00:00 | Prairie View v Incarnate Word | W | 9-40 |
| NCAAF | 2021/09/02 23:00 | Incarnate Word v Youngstown State | L | 41-44 |
| NCAAF | 2021/04/17 16:00 | Sam Houston State v Incarnate Word | L | 42-14 |