Stadium: Hardy M. Graham Stadium Round: 1
Home Manager: Jason Simpson Away Manager: Chris Hatcher
| NCAAF | 2021/09/02 23:00 | Tennessee Tech v Samford | W | 14-52 |
| NCAAF | 2021/04/17 17:00 | Mercer v Samford | W | 20-44 |
| NCAAF | 2021/03/27 17:00 | Samford v The Citadel | W | 55-7 |
| NCAAF | 2021/03/20 17:00 | VMI v Samford | L | 38-37 |
| NCAAF | 2021/03/13 18:00 | Wofford v Samford | W | 31-37 |
| NCAAF | 2021/03/06 18:00 | Samford v Furman | L | 37-44 |
| NCAAF | 2021/02/27 18:00 | Western Carolina v Samford | W | 27-55 |
| NCAAF | 2021/02/20 18:00 | Samford v East Tennessee State | L | 17-24 |
| NCAAF | 2021/09/03 00:00 | Tennessee Martin v Western Kentucky | L | 21-59 |
| NCAAF | 2021/04/11 20:00 | Tennessee Tech v Tennessee Martin | W | 7-40 |
| NCAAF | 2021/04/03 18:00 | SE Missouri St v Tennessee Martin | L | 21-16 |
| NCAAF | 2021/03/28 19:00 | Tennessee Martin v Tennessee State | L | 24-26 |
| NCAAF | 2021/03/21 19:00 | Tennessee Martin v Austin Peay | W | 37-34 |
| NCAAF | 2021/03/14 18:00 | Jacksonville State v Tennessee Martin | L | 37-20 |
| NCAAF | 2021/03/07 19:00 | Eastern Illinois v Tennessee Martin | W | 15-28 |
| NCAAF | 2021/02/28 20:00 | Tennessee Martin v Murray State | L | 10-14 |