Stadium: Dana J. Dykhouse Stadium Round: 1
Home Manager: John Stiegelmeier Away Manager: Mark Farley
| NCAAF | 2021/02/20 01:00 | South Dakota State v Northern Iowa | L | 24-20 |
| NCAAF | 2019/12/07 19:00 | Northern Iowa v South Dakota State | W | 13-10 |
| NCAAF | 2019/11/16 20:00 | Northern Iowa v South Dakota State | L | 7-38 |
| NCAAF | 2018/10/20 21:00 | Northern Iowa v South Dakota State | W | 24-9 |
| NCAAF | 2017/12/02 20:00 | Northern Iowa v South Dakota State | L | 22-37 |
| NCAAF | 2017/10/14 19:00 | South Dakota State v Northern Iowa | W | 18-38 |
| NCAAF | 2021/10/16 21:00 | South Dakota v Northern Iowa | L | 34-21 |
| NCAAF | 2021/10/09 18:00 | Northern Iowa v North Dakota State | L | 20-34 |
| NCAAF | 2021/10/02 21:00 | Youngstown State v Northern Iowa | W | 7-34 |
| NCAAF | 2021/09/12 01:00 | Northern Iowa v CS Sacramento | W | 34-16 |
| NCAAF | 2021/09/04 20:30 | Northern Iowa v Iowa State | L | 10-16 |
| NCAAF | 2021/04/10 21:00 | North Dakota State v Northern Iowa | L | 23-20 |
| NCAAF | 2021/03/27 16:00 | Northern Iowa v Western Illinois | W | 34-20 |
| NCAAF | 2021/03/20 21:00 | Missouri St v Northern Iowa | L | 13-6 |
| NCAAF | 2021/10/16 17:00 | South Dakota State v Western Illinois | W | 41-17 |
| NCAAF | 2021/10/09 19:00 | SO Illinois v South Dakota State | L | 42-41 |
| NCAAF | 2021/10/02 23:00 | Utah Tech v South Dakota State | W | 7-55 |
| NCAAF | 2021/09/25 17:00 | South Dakota State v Indiana State | W | 44-0 |
| NCAAF | 2021/09/11 23:00 | South Dakota State v Lindenwood | W | 52-7 |
| NCAAF | 2021/09/04 01:00 | South Dakota State v Colorado State | W | 42-23 |
| NCAAF | 2021/05/16 18:00 | Sam Houston State v South Dakota State | L | 23-21 |
| NCAAF | 2021/05/08 16:00 | Delaware v South Dakota State | W | 3-33 |