[34] Iowa 27-17 Iowa State [62] 2021-09-11 20:30
Stadium: Jack Trice Stadium Round: 1
Home Manager: Matt Campbell Away Manager: Kirk Ferentz
Head to Head
| NCAAF | 2019/09/14 20:00 | Iowa v Iowa State | W | 18-17 |
| NCAAF | 2018/09/08 21:00 | Iowa State v Iowa | W | 3-13 |
| NCAAF | 2017/09/09 16:00 | Iowa v Iowa State | W | 44-41 |
| NCAAF | 2016/09/10 23:30 | Iowa v Iowa State | W | 42-3 |
| NCAAF | 2015/09/12 20:45 | Iowa State v Iowa | W | 17-31 |
| NCAAF | 2014/09/13 19:30 | Iowa v Iowa State | L | 17-20 |
| NCAAF | 2012/09/08 12:00 | Iowa v Iowa State | L | 6-9 |
| NCAAF | 2011/09/10 12:00 | Iowa State v Iowa | L | 44-41 |
Home History
| NCAAF | 2021/09/04 19:30 | Indiana v Iowa | W | 6-34 |
| NCAAF | 2020/12/12 20:30 | Wisconsin v Iowa | W | 7-28 |
| NCAAF | 2020/12/05 20:30 | Iowa v Illinois | W | 35-21 |
| NCAAF | 2020/11/27 18:00 | Nebraska v Iowa | W | 20-26 |
| NCAAF | 2020/11/21 20:30 | Iowa v Penn State | W | 41-21 |
| NCAAF | 2020/11/14 00:00 | Iowa v Minnesota | W | 35-7 |
| NCAAF | 2020/11/07 17:00 | Michigan State v Iowa | W | 7-49 |
| NCAAF | 2020/10/31 19:30 | Northwestern v Iowa | L | 21-20 |
Away History
| NCAAF | 2021/09/04 20:30 | Northern Iowa v Iowa State | W | 10-16 |
| NCAAF | 2021/01/02 21:00 | Oregon v Iowa State | W | 17-34 |
| NCAAF | 2020/12/19 17:00 | Oklahoma v Iowa State | L | 27-21 |
| NCAAF | 2020/12/05 20:30 | West Virginia v Iowa State | W | 6-42 |
| NCAAF | 2020/11/27 17:00 | Iowa State v Texas | W | 23-20 |
| NCAAF | 2020/11/21 21:00 | Kansas State v Iowa State | W | 0-45 |
| NCAAF | 2020/11/08 00:00 | Baylor v Iowa State | W | 31-38 |
| NCAAF | 2020/10/31 16:00 | Iowa State v Kansas | W | 52-22 |