[11] Santos Laguna 1-0 Cruz Azul [12] 2021-01-11 01:06
Stadium: Estadio TSM Corona Round: 1
Referee: Mario Humberto Vargas Mata Home Manager: Guillermo Almada Away Manager: Luis Armando Gonzalez Bejarano
Head to Head
| Mexico - Liga MX | 2020/07/26 02:00 | Cruz Azul v Santos Laguna | L | 2-0 |
| Mexico - Liga MX | 2020/01/25 23:00 | Cruz Azul v Santos Laguna | L | 3-0 |
| Mexico - Liga MX | 2019/11/11 00:45 | Santos Laguna v Cruz Azul | W | 3-1 |
| Mexico - Liga MX | 2019/02/16 23:00 | Cruz Azul v Santos Laguna | W | 1-2 |
| Mexico - Liga MX | 2018/08/26 23:00 | Santos Laguna v Cruz Azul | D | 1-1 |
| Mexico - Liga MX | 2018/02/26 00:00 | Santos Laguna v Cruz Azul | W | 2-0 |
| Mexico - Liga MX | 2017/09/16 22:00 | Cruz Azul v Santos Laguna | L | 2-1 |
| Mexico - Beker | 2017/03/15 01:00 | Santos Laguna v Cruz Azul | L | 1-3 |
Home History
| Mexico - Liga MX | 2020/11/22 01:00 | Santos Laguna v Pachuca | L | 0-3 |
| Mexico - Liga MX | 2020/11/09 01:06 | Santos Laguna v Mazatlan FC | W | 4-0 |
| Mexico - Liga MX | 2020/11/03 03:00 | Leon v Santos Laguna | L | 2-1 |
| Mexico - Liga MX | 2020/10/26 01:06 | Santos Laguna v Atletico San Luis | W | 2-1 |
| Mexico - Liga MX | 2020/10/19 00:06 | Santos Laguna v Pachuca | D | 1-1 |
| Mexico - Liga MX | 2020/10/12 00:06 | Santos Laguna v Tijuana | W | 2-0 |
| Mexico - Liga MX | 2020/10/03 00:30 | Puebla v Santos Laguna | W | 0-2 |
| Mexico - Liga MX | 2020/09/20 17:00 | Toluca v Santos Laguna | W | 1-2 |
Away History
| CONCACAF Champions Cup | 2020/12/17 03:30 | Los Angeles FC v Cruz Azul | L | 2-1 |
| Mexico - Liga MX | 2020/12/07 00:30 | Unam Pumas v Cruz Azul | L | 4-0 |
| Mexico - Liga MX | 2020/12/04 03:00 | Cruz Azul v Unam Pumas | W | 4-0 |
| Mexico - Liga MX | 2020/11/30 00:30 | Cruz Azul v Tigres UANL | L | 0-1 |
| Mexico - Liga MX | 2020/11/27 01:00 | Tigres UANL v Cruz Azul | W | 1-3 |
| Mexico - Liga MX | 2020/11/08 03:00 | Cruz Azul v Unam Pumas | L | 1-2 |
| Mexico - Liga MX | 2020/11/01 03:06 | Monterrey v Cruz Azul | L | 1-0 |
| Mexico - Liga MX | 2020/10/25 23:30 | Chivas Guadalajara v Cruz Azul | W | 0-2 |